Recently, research into the use of probiotics (live micro organisms that confer a health benefit) for colic has been rapidly gaining momentum. Infants with colic are reported to have increased concentrations of gas forming organisms and proteobacteria such as Escherichia coli in their gut.8 20 21 22 Colonisation with certain intestinal micro organisms, such as Bifidobacterium and Lactobacillus species, along with increased intestinal microbial diversity, may protect against infant distress.8 23 Probiotics enhance the mucosal barrier and promote microbial diversity in the gut.24 25 They may reduce concentrations of proteobacteria and gas forming coliform and reduce intestinal inflammation.26 27 28 29 30 A recent meta analysis of three small, randomised controlled trials of breastfed infants with colic reported that Lactobacillus reuteri noticeably reduced crying time at 21 days post supplementation.31 However, one trial was unblinded,32 two included only infants with mothers http://www.pandorabraceletjewelry.comon dairy free diets,32 33 and none used validated measures of infant distress. No trials have included formula fed infants, which is relevant because colic is associated with early breastfeeding cessation.4 Despite these major limitations, the use of probiotics for colic has been rapidly taken up internationally.
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